A BRIEF HISTORY OF CHLOROFORM
Chloroform is a hazardous liquid compound which is also known as Trichloromethane and has a chemical formula of CHCl3. Chloroform is one of the original anaesthetics and was used in early operating procedures and by dentists. The surgeon or dentist would put liquid Chloroform on a cloth and hold it over the patient’s nose until it they became unconscious. Chloroform appears as a clear, colourless liquid with a typically sweet organic smell which many people find quite pleasant.
When using or working with Chloroform it is essential that appropriate PPE (Personal Protective Clothing) is used. Protective gloves should be worn when handling the material. Please check with the manufacturer for details of compatibility. Additionally, safety goggles and protective clothing should be worn.
If exposed to the vapours of Chloroform, an operator will become dizzy and light-headed. Exposure to concentrated vapours will cause an operator to become unconscious. It is therefore essential than Chloroform is handled under fume extraction. Where ventilation is inadequate, a respirator should be worn. This must have an organic vapour cartridge and the manufacturer should be consulted regarding compatibility.
It is essential that operators do not eat or drink when handling Chloroform. It is harmful if swallowed and causes skin irritation. Chloroform is suspected of causing cancer and there is limited evidence to support its carcinogenic effects. Exposure to Chloroform can cause damage to specific organs, especially if the exposure is prolonged or repeated. Exposure to Chloroform can cause damage to the unborn child so pregnant women should never work with or handle Chloroform. If you feel unwell following exposure to Chloroform, you should seek medical assistance. Chloroform is classified as Toxic for transport.
Chloroform has uses in a number of manufacturing processes and in organic synthesis. It is used as a precursor in the manufacture of Teflon, the widely used non-stick material. Chloroform is also used in the bonding of certain plastics.
Chloroform is heavier than water and has a Specific Gravity (S.G.) of 1.5. As Chloroform is immiscible with water (it does not mix as it is heavier than water), it is often used in organic separation for extraction purposes. A separation funnel is used and the organic mixture settles down in the Chloroform layer at the bottom of the vessel whilst the aqueous mixture stays on top.
One of the foremost Chloroform suppliers are ReAgent, a well-established chemical manufacturing company based in the UK
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Utopian Surgery
Dramatis Personae
Anaesthesia and Anaesthetics
Opioids: past, present and future
Anaesthesia and Pain History Resources
Professor James Simpson and chloroform
Anaesthesia and Anaesthetics in Contemporary Medicine
info@chloroform.co.uk